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Read through for an excerpt from our recently published article in WIRED:
If you wanted to create better blackberries, you could try to breed a variety without the seeds that get stuck in your teeth. Or one without the thorns that make the berries hard to pick. Or you could aim for more environmentally efficient plants that produce more berries per acre with less water and fewer chemicals.
With decades of work and a fair amount of luck, you might achieve one of those goals.
But a North Carolina startup called Pairwise is using the gene-editing technology called Crispr to try to achieve all those goals at once, crafting seedless, thornless, higher-yielding blackberry plants—and in a matter of years rather than decades.
That’s the promise of modern genomics: introducing speed, precision, and the ability to solve multiple problems at once to the glacially slow, haphazard, one-tweak-at-a-time world of crop breeding.
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DURHAM, N.C. — Pairwise today introduced Fontana™, a new blackberry developed for commercial fresh-market production. With a compact plant architecture, earlier and more condensed fruiting window, and high-quality fruit, the Fontana blackberry is designed to help growers increase productivity while simplifying production and harvest.
"We started with a great berry and improved the plant around it," said Ryan Bartlett, Chief Technology Officer at Pairwise. "Fontana helps growers produce significantly more fruit per acre while simplifying some of the most labor-intensive parts of blackberry production, making it a true win-win-win — for growers, for retailers, and for consumers, who enjoy high-quality, delicious fruit that's more seasonally available.”
Fontana is built on a proven Plant Sciences Genetics (PSG) variety known for its exceptional flavor and fruit quality. Pairwise developed the Fontana blackberry with a compact architecture that reaches approximately 3.5 to 5 feet, about half the height of a conventional blackberry plant.
The smaller architecture allows Fontana blackberries to be planted at higher densities while requiring no pruning and minimal trellis labor. Combined with an earlier and more concentrated harvest window, these characteristics can increase production per acre and make plants easier to manage, harvest and grow in more locations with an early production window.
Fontana plants offer several potential advantages for commercial growers:
- Earlier, higher yield: Higher-density planting and an earlier, more condensed harvest window can increase yield per acre.
- A consistent, great berry: One blackberry grown across regions and seasons, so every clamshell delivers the same delicious eating experience.
- Easier management: Fontana’s compact architecture makes fruit easier to access at harvest.
By the numbers
First in a pipeline of improved blackberry varieties
Fontana is the first in a pipeline of blackberry varieties under development, which include thornless and seedless blackberries. Together, the pipeline is intended to improve the economics and sustainability of blackberry production while delivering high-quality fruit with characteristics consumers value.
About Pairwise
Pairwise is committed to building a healthier world through better crop varieties and plant innovation. Powered by its proprietary Fulcrum® Platform, Pairwise accelerates the development of climate-resilient, nutritious, and sustainable crops. As a trusted partner to global industry leaders and nonprofit institutions, Pairwise helps breeders move faster while transforming food and agriculture for farmers, consumers, and the planet. Founded in 2017 and based in Durham, NC, Pairwise is committed to delivering innovation that makes food easier to grow and better to eat. For more information, visit www.pairwise.com.
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Read through for an excerpt from our recently published article in AgFunderNews:
Gene editing is rapidly expanding beyond row crops into specialty crops, animals, and microbes, says Pairwise, which has seen a “dramatic uptick” in licensing deals for its Fulcrum platform over the past 12-18 months and now has 25 licensees covering more than 30 species.
Unlike transgenic plants—which are classified as GMOs as foreign DNA from another species is introduced—gene editing involves tinkering with species’ native genes, which eases the regulatory pathway in a growing number of markets and can deliver speed and precision, two potential gamechangers in breeding, says COO Ian Miller, PhD.
“We’re really enthusiastic about the direction that the regulatory environment is going worldwide,” adds Miller, who says Pairwise is seeing growing interest in Europe now that the EU has enshrined a new, simpler regulatory framework for plants made using new genomic techniques.
“I think there’s an understanding that in many cases, what comes out from gene editing is equivalent to conventional breeding because we’re working within the plant’s own genes. The beauty of gene editing is that if it sits somewhere in the gene pool, you can bring it to bear for a problem.”
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ST. LOUIS, MO. and DURHAM, NC, June 23, 2026 — Pairwise, a global innovator in agriculture, today announced a licensing agreement with Agragene, a sustainable agricultural technology company developing biological crop pest protection, granting access to Pairwise's Fulcrum® CRISPR platform.
Agragene will integrate Fulcrum® tools into the development of its Precision-Guided Sterile Insect Technology (pgSIT), which produces sterile male insects for proactive control of pest populations, increasing yields for growers. Agragene's first product (KNOCKOUT™ SWD) targets spotted wing drosophila (SWD), an invasive fly responsible for more than $1billion annually in losses to U.S. and Canadian berry, cherry, and other soft fruit crops. Because the technology is highly species-specific, it suppresses only the target pest, leaving crops, beneficial insects such as bees and ladybugs, and the surrounding environment unaffected.
“Growers are running out of options as pests develop resistance to conventional insecticides, and they are looking for tools that are safe, targeted, and sustainable,” said Bryan Witherbee, President and CEO of Agragene. “Our mission is to deliver cleaner pest control that supports healthier crops and a healthier planet. Access to Fulcrum® strengthens the editing technology behind our pgSIT platform and helps us move faster from field trials towards practical tools growers can use.”
“Pairwise works across all of agriculture, which means partnering with people closest to the problems,” said Dr. Tom Adams, CEO of Pairwise. “Agragene is the first to apply Fulcrum® in insect systems, and it's exactly the kind of creative use we hoped good tools would find."
The Pairwise Fulcrum® platform includes proprietary CRISPR editing tools, enzymes, and trait libraries that enable precise genetic changes. Pairwise developed and proved the platform in its own breeding programs and makes it available to partners and licensees worldwide for research and commercial purposes.
About Agragene
Agragene is a sustainable agricultural technology company based in St. Louis, Missouri, developing biological crop pest protection products. Using Precision-Guided Sterile Insect Technology (pgSIT), a CRISPR-based platform, Agragene provides sterile male insects to reduce and control pest populations while reducing reliance on traditional insecticides. Founded in 2017, the company is pursuing commercial product launch in the U.S. and a licensing strategy worldwide. For more information, visit www.agragene.com
About Pairwise
Pairwise is agriculture's gene editing powerhouse, building a healthier world through partnership and plant innovation. Co-founded by early pioneers of CRISPR, Pairwise's Fulcrum® Platform accelerates the development of climate-resilient, nutritious, and sustainable crops. As a trusted partner to global industry leaders and nonprofit institutions, Pairwise helps breeders move faster while transforming food and agriculture for farmers, consumers, and the planet. Founded in 2017 and based in Durham, NC, Pairwise is committed to delivering innovation that makes food easier to grow and better to eat. For more information, visit www.pairwise.com.
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develop more resilient crops, lower the environmental impact and strengthen European food security
This decision positions European growers to access the same modern breeding tools already available to their counterparts globally.
Dan Jenkins, VP of Regulatory and Government Affairs at Pairwise:
"European policymakers deserve credit for keeping this legislation moving, and that persistence paid off. With Europe now on board, growers there will have access to the same modern breeding tools already available to their counterparts in the rest of the world."
Tom Adams, CEO of Pairwise:
"Policies like this matter because they connect innovation to the field and the table. This is exactly the kind of work Pairwise strives to do with our partners. Varieties that are more climate resilient, disease tolerant, and require fewer inputs to grow can now reach European growers and markets. That's good for food security, good for trade, and good for consumers."
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Below is an update originally shared with our newsletter audience, capturing recent progress across Pairwise’s products, platform, and policy momentum.
Early Market Validation of Our Berry Business
This year marked an important milestone for the power of our Fulcrum® platform: the first outdoor field trials for blackberry. These trials allow us to observe performance across two distinct growing environments, the US and Colombia, and begin translating our genetics into real-world production settings. Learnings from this season will help shape the broader field program planned for the coming years.
Early observations from both sites have been incredibly encouraging. Our high-density production system has the potential to reshape economics in the caneberry category. The compact blackberry may not only reduce land use but also increase yields by 50+% based on our greenhouse trials. While still early in the outdoor field trials, the initial signals give us confidence in our path toward future commercialization and in reaching the next set of technical and commercial milestones in 2026.
This year, we hit another powerful milestone: the first commercial sale of edited blackberries in the world. In Colombia, working with a Production Partner and Retailers, the berries have been sold to consumers, who have responded positively to the fruit. Each clamshell includes a QR code that links consumers directly to information on blackberries and the technology behind them, ensuring transparency and helping introduce consumers to the benefits of innovation in fresh produce. This early market validation adds to our confidence in the significant berry opportunities ahead.
The Innovation is Real, Translational and Accelerating
One of the newest additions to our greenhouses is our seedless blackberry — a juicy, delicious berry without the tough seeds that pops in your mouth. This incredible berry represents a true game-changer for specialty crops. Again and again in the market, we’ve seen that seedlessness outperforms; people love convenient, snackable fruits.
This thesis is also a core part of the joint venture we launched with Sun World International in September, where together we’re working to create the world’s first pitless cherry. Traditionally, breeding something like this could take a century. We believe we can achieve it in a decade. (See Bloomberg article about our partnership here).
Innovation in agriculture has historically run on century-long timelines. We're demonstrating in real time that doesn't have to be the case. Our platform approach to AgTech enables the architecture of continuous innovation. When we compress breeding cycles and translate traits across crops, we open possibilities that weren't feasible in entire categories – from sustainability and disease tolerance to nutrition and yield. The sky, not the edge of the field, is the limit.
Global Adoption of Fulcrum® Platform Continues
Over the past six months, we've signed agreements with organizations that continue to validate the value of genome editing and Pairwise’s Fulcrum® platform. Each one of these is proof that our proprietary CRISPR platform is becoming an essential infrastructure. These include:
- Academic licenses signed with Kansas State, University of Wisconsin and University of Florida (UF/IFAS)
- International Rice Research Institute: Global research to support rice as a staple crop
- Mars: Research in cacao (See CNBC article here)
- Genus: Validation of our technology beyond plant applications – a first!
- Enza Zaden: A Netherlands-based global vegetable seed company that is using Fulcrum in its research, reflecting growing adoption of genome editing/NGTs in Europe (See the Packer article here)
Here is a snapshot of our current licensing footprint:
Game-Changing Policy Progress in the EU
A policy agreement was reached, paving the way for opening the European market to edited plant varieties for both cultivation and import. A final vote still needs to occur, which is expected in late Q1/early Q2 of 2026, but the policy the European Council and the European Parliament agreed upon creates a category for these plants to enter the market with no patent restrictions, food labeling, or traceability requirements. After the vote, the European Commission will embark upon writing the regulations, which is expected to take approximately 24 months. We eagerly await the opening of the European market!
This is only part of our work. Catch us at the World Agri-Tech Innovation Summit in SF March 17-18, 2026 and find future updates of our whereabouts on LinkedIn.
Pairwise is one of a select group of companies recognized this year for using biotechnology to address the challenges of a warming world. The feature highlights our pipeline of gene-edited crops, including short-stature corn and blackberries, designed to thrive under increasingly harsh conditions, and our partnerships with Bayer and Corteva to scale climate-resilient traits across agriculture.
The International Institute of Tropical Agriculture (IITA), in partnership with Pairwise, a US-based technology company pioneering the application of gene editing in food and agriculture, is delighted to announce a grant of US$ 3,874,356 from the Bill & Melinda Gates Foundation. This grant will support the “Yam Optimized Architecture through Gene Editing (YOAGE)” project, an innovative project aimed at delivering novel genetic variation to yam (Dioscorea spp.) that improves plant architecture. The project goal is to reduce labor and environmental impact associated with traditional plant staking while also enabling mechanized farming in Nigeria, where yam is an important staple food crop.
The 4-year YOAGE project will focus on developing yam varieties with optimized growth characteristics, improving cultivation practices, and boosting productivity and profitability while collaborating with various stakeholders, including local farmers, agricultural experts, and policymakers. Yam is the second most important root and tuber crop in sub-Saharan Africa after cassava, with a production of about 75 million metric tons (FAO, 2021) and provides about 200 kilocalories daily to over 400 million people in the low-income and food-deficit countries of the tropics. Africa produces over 97% of the global yams, with Nigeria alone accounting for about 66% of the world’s total (FAO, 2021). In West Africa, particularly in Nigeria, yam is not only a staple crop but also plays a central role as a traditional flagship crop deeply intertwined with societal norms, fulfilling various social and religious functions.
Despite this importance, yam cultivation faces several challenges, such as high costs of planting materials and labor, declining soil fertility, low-yielding varieties that require staking, and increased pest and disease pressures due to intensified farming. While conventional breeding has improved yam varieties for pest resistance, adaptability, and quality, it has made limited progress in optimizing plant architecture for mechanized farming. The YOAGE project will leverage advanced gene editing tools to overcome these challenges and support global food security, particularly in the face of climate change, resource limitations, and shifting consumer demands.
Leena Tripathi, IITA Eastern Africa Hub Director, Biotechnology Program Lead, and YOAGE Principal Investigator, said: “Receiving this grant from the Gates Foundation marks a pivotal advancement in transforming yam production through innovative gene editing technologies. By developing improved bushy-types of yam varieties, we aim to reduce labor demands, enhance farming efficiency, and boost sustainability. Ultimately, our goal is to elevate farmers’ livelihoods and strengthen food security.”
The YOAGE project aims to develop these varieties by identifying the genes controlling plant growth, optimizing gene editing to develop semi-dwarf varieties, and analyzing the impacts of these changes on labor and gender dynamics. By addressing the technical and environmental challenges of yam production, the project is expected to significantly improve productivity and farmers’ income, contributing to the global goal of sustainable agriculture and food security.
The Gates Foundation selected IITA and Pairwise for the grant because of their proven records in agricultural innovations and community engagements in the region. IITA is a global center of excellence for yam breeding and a genetic improvement source of new and improved yam genotypes for major yam growers in Africa. Also, it has a long tradition and experience in the breeding and genetics of yam, a well-established yam breeding network that connects several national programs from major yam-growing areas in Africa.
Pairwise is pioneering the application of gene editing technology in food and agriculture through its Fulcrum™ Platform, the most extensively developed and validated toolbox for CRISPR application in plants. As one of the first companies in the world to commercialize gene-edited consumer food and agricultural products, Pairwise brings together leaders in agriculture, technology, and consumer foods to harness the transformative potential of new genomics technologies to create innovative new products.
“The Gates Foundation sees gene editing as an opportunity to more rapidly advance important crops like yam, following a path established through a long history of crop breeding. Through gene editing, we can keep all the favorable characteristics of adapted crops, such as nutrition and climate resilience, while removing characteristics like vining in yams that limit a crop’s potential. By partnering IITA with Pairwise, we have brought together top scientists to tackle this important challenge and drive adoption of improved varieties for smallholder farmers.” explained Dr Nicolas Bate, the Senior Program Officer at Bill & Melinda Gates Foundation.
Pairwise Director of Trait Strategy and Testing, Dr Shai Lawit, added: “Gene editing offers a revolutionary approach to solving global challenges in agriculture. Through important public-private initiatives like this one with IITA, the Bill & Melinda Gates Foundation, and Pairwise, we are not only improving crop production; we’re also empowering smallholder farmers, reducing environmental impacts, and advancing food security to narrow the global nutritional deficit, which is especially prevalent in developing countries.”
Through this combined work, the YOAGE project will demonstrate the importance of public-private partnerships in unlocking the benefits of gene editing in Nigeria and Africa at large.
About IITA
The International Institute of Tropical Agriculture (IITA) is a not-for-profit institution that generates agricultural innovations to address Africa’s most pressing challenges of hunger, malnutrition, poverty, and natural resource degradation. Working with various partners across sub-Saharan Africa, IITA improves livelihoods, enhances food and nutrition security, increases employment, and preserves natural resource integrity. IITA is a member of CGIAR, a global agriculture research partnership for a food and nutrition secure future.
About Pairwise:
Pairwise is pioneering the application of gene editing technology in food and agriculture. The company brings together leaders in agriculture and tech to harness transformative genomic technologies to create innovative new products that benefit society. Pairwise is working to develop new varieties of fruits, vegetables, and large-acre crops, and to partner with organizations that seek to deliver innovation across the plant-based economy. Backed by industry leading investors Deerfield, Aliment Capital, Leaps by Bayer, Temasek, and Corteva Catalyst, Pairwise raised $40 million in a successful funding round in September 2024, bringing total fundraising to $155 million. The company was co-founded by the company’s CEO Dr. Tom Adams and agriculture innovator Dr. Haven Baker, with scientific co-founders J. Keith Joung, Lead Translator at Arena BioWorks; David Liu, Director of the Merkin Institute of Transformative Technologies in Healthcare, and Vice-Chair of the Faculty at the Broad Institute of Harvard and MIT; and Feng Zhang, McGovern Investigator and a professor at MIT. For more information about the differentiating Pairwise Fulcrum™ Platform here.
Genome editing with CRISPR and other tools is an exciting new technology with myriad applications from human health to industrial biotechnology. Gene editing allows small but precise changes in DNA sequences to turn genes on or off or modulate their activity. It is an extremely active area for investment, particularly since the announcement of the first CRISPR-based human gene therapy approval November of 2023. Editing technology also has tremendous potential for applications in agriculture and this week there was an announcement of a new partnership between a major global agriculture company, Corteva, and a genome editing company called Pairwise. This sort of development and innovation is important because the global agricultural sector faces many challenges and opportunities including:
- Feeding a growing global population without encroaching on remaining wild lands
- Growing crops in an environment that increasingly involves more heat and water stress events driven by climate change
- Striving to reduce the carbon footprint of farming while also aiding footprint reductions for other industries such as animal production, fuels and plastics
- Playing a positive role in net global carbon sequestration
- Managing new and intensified pest challenges driven by pesticide resistance and climate shifts
- Creating crops with novel consumer-oriented characteristics to enhance food enjoyment and health
Indianapolis and Durham, N.C. (Sept 17th 2024) – Corteva, Inc. (NYSE: CTVA), a global leader in agricultural technology and Pairwise, a technology company pioneering the application of gene editing in food and agriculture, announced a collaboration today to accelerate the delivery of advanced gene editing solutions to farmers, ultimately benefitting both the environment and everyday consumers. Gene editing uses a plant’s own DNA to make precise improvements, providing growers with another critical tool to keep pace with the challenges facing food production, including those presented by climate change.
Anchoring the collaboration is Corteva’s $25 million equity investment in Pairwise, made under the umbrella of Corteva Catalyst, the company’s new investment and partnership platform focused on accessing agricultural innovation to drive value creation. The investment aims to help expand the reach and benefits of gene editing to a wide variety of staple and specialty crops.
In addition, Corteva and Pairwise have formed a joint venture to accelerate and expand the delivery of advanced gene edited technologies aimed at increasing crop yield for food, fuel and fiber production, despite increasing climate change.
The joint venture, which spans five years, will leverage both companies’ advanced gene editing capabilities to accelerate the pace of gene edited products by generating and evaluating unique gene edits across multiple traits in a range of crops. Building on Corteva’s longstanding leadership in plant breeding and genetics, the companies will collaborate on the development and deployment of gene edited products that are more resilient to extreme weather events and climate change.
“Gene editing is a transformational technology for agriculture that will advance climate resilience in food production and drive the increased farm productivity required to effectively feed and fuel the world’s growing population,” said Sam Eathington, Corteva’s chief technology and digital officer. “As a gene editing technology leader ourselves, we are proud to work with Pairwise to accelerate the benefits of gene editing not only to farmers, but ultimately to those who rely on the availability of sustainably grown and affordable food – and that’s all of us.”
“Gene editing is poised to revolutionize agriculture, enabling the cultivation of crops that are more adaptive to climate change, are more nutritious and convenient for consumers, and deliver greater economics for growers,” said Tom Adams, Pairwise Co-Founder and CEO. “Through our Fulcrum™ Platform, we’re proud to be at the helm of applying this transformative technology in agriculture and, alongside partners like Corteva, accelerate the realization of these benefits across global stakeholders.”
Pairwise is a leader in using gene editing to make differentiated crops. Last year, the company launched the first CRISPR food in North America, and has multiple products in development across significant crops, including corn, soy, wheat, canola, blackberries, and more. The Pairwise Fulcrum™ Platform includes proprietary gene editing tools that provide the ability to not only turn a characteristic on or off but also, with base editing and related technologies, “tune” it to find it’s sweet spot for highest performance. Pairwise’s novel editing tools allow scientists to precisely tailor a wide range of genetic variation to develop new, distinctive plant varieties much faster and more effectively than through conventional breeding alone.
This is the first joint venture and major equity investment in gene editing made by Corteva Catalyst, the company’s new investment and partnership platform. The investment reflects Corteva’s nearly century-long track record (through its Pioneer brand) of championing innovation through partnerships, including with the global scientific community.
About Corteva:
Corteva, Inc. (NYSE: CTVA) is a publicly traded, global pure-play agriculture company that combines industry- leading innovation, high-touch customer engagement and operational execution to profitably deliver solutions for the world’s most pressing agriculture challenges. Corteva generates advantaged market preference through its unique distribution strategy, together with its balanced and globally diverse mix of seed, crop protection, and digital products and services. With some of the most recognized brands in agriculture and a technology pipeline well positioned to drive growth, the company is committed to maximizing productivity for farmers, while working with stakeholders throughout the food system as it fulfills its promise to enrich the lives of those who produce and those who consume, ensuring progress for generations to come. More information can be found at www.corteva.com.
Media Contacts:
Corteva:
Bethany Shively
(202) 997-9438
Pairwise, a company pioneering the application of CRISPR technology in food and agriculture, has granted a full technology license to its proprietary Fulcrum™ Platform to Solis Agrosciences. Through this license, Solis will be using Pairwise’s tools to drive innovative solutions to their clients’ global food and climate challenges.
Licensees of the Fulcrum Platform can receive access to Pairwise’s full suite of novel technologies and proprietary tools for applying CRISPR to research, develop, and commercialize products with differentiated plant genetics.
Solis provides robust product design and R&D services to many different plant science clients, offering access to technologies that accelerate scientific breakthroughs and the path to commercialization. Solis will first leverage the Fulcrum Platform to develop new traits. Once a product is ready to move from the R&D stage to commercialization, Solis’ clients can obtain a commercial license through Pairwise to take their products to market.
“Our experienced team utilizes advanced technology platforms to reduce our clients’ product development timelines in traditional row crops as well as specialty crops,” said Susan Martino-Catt, Solis Chief Operating Officer. “Pairwise is pioneering CRISPR in agriculture, and bringing new, advanced solutions to the marketplace. Their Fulcrum Platform can improve R&D efficiency and provides a streamlined commercial pathway for our clients’ products. We are excited to use the Fulcrum Platform to support our current clients and also to engage with a new set of clients, helping them to advance their product pipelines.”
“CRISPR has the potential to transform agriculture and provide enormous benefits to consumers, growers, and the environment,” said Ian Miller, Pairwise Chief Development Officer. “Pairwise’s novel tools and commercial rights have been used to create and deliver new products across many crops, including corn, wheat, soy, canola, bananas, coffee, berries, and cherries. In addition to the products we’ve created, we’re excited to now empower other organizations – like Solis and, by extension, their clients – to develop their own CRISPR-edited products that will deliver the enormous potential of the technology.”
The Fulcrum Platform includes Pairwise-developed gene editing tools for cutting, base editing, and templated editing – a toolbox which enables not only turning a characteristic on or off, but also tuning it – like a dimmer switch to dial a trait up or down, such as creating a new type of corn with up to 20% more kernel rows.
Important technologies which enable the Fulcrum Platform include Pairwise’s novel SHARC™, base editing, and the REDRAW™ templated editing system.
- SHARC is a proprietary enzyme that works well for cutting, base editing, and REDRAW editing, and is the foundation for a proprietary and comprehensive genome editing toolbox.
- Pairwise’s proprietary base editing and diversification tools enable innovators to “tune” CRISPR edits with great precision. Alongside REDRAW, Pairwise’s templated editing solution, these tools allow access to a wide range of genetic variation, which is key to creating new, distinctive plant varieties much faster and more effectively than conventional breeding.
“We look forward to the team at Solis using our Fulcrum Platform to accelerate their clients’ product research and working with those clients on licensing commercial rights in the future,” said Miller.
Whether through licensing, collaborations, or in-house product development, scientists leverage Pairwise’s leading CRISPR tools, IP, and full Fulcrum Platform for applications in crops of global importance, including climate-friendly short corn, bananas and coffee, blackberries, leafy greens, and more.
Learn more about licensing the Fulcrum Platform, as well as opportunities to develop new products through a collaborative partnership with Pairwise, here.
About Pairwise:
Pairwise is pioneering the application of CRISPR technology in food and agriculture. The company brings together leaders in agriculture, technology, and consumer foods to harness the transformative potential of new genomics technologies to create innovative new products. Pairwise is working to develop new varieties of crops, and to partner with organizations that seek to deliver innovation across the plant-based economy. Backed by industry leading investors Deerfield, Aliment Capital, Leaps by Bayer, and Temasek, Pairwise raised $90 million in a successful series B funding round in February 2021, bringing total fundraising to $115 million. The company was founded by Chief Executive Officer Tom Adams and Chief Business Officer Haven Baker, with scientific co-founders J. Keith Joung, Lead Translator at Arena BioWorks; David Liu, Director of the Merkin Institute of Transformative Technologies in Healthcare, and Vice-Chair of the Faculty at the Broad Institute of Harvard and MIT; and Feng Zhang, McGovern Investigator and a professor at MIT. For more information, visit Pairwise.com, and learn more about the differentiating Pairwise Fulcrum™ Platform here.
About Solis Agrosciences:
Solis Agrosciences is the trusted partner for high-quality AgTech research services. We generate gene-edited and transgenic crops, plant phenotype and efficacy data, and individually tailored research solutions for our startup and corporate customers. Solis’ highly trained and industry-experienced scientists operate in state-of-the-art facilities in the 39 North Ag Biotech district of St. Louis, Missouri. To partner with Solis, visit SolisAgrosciences.com.
Pairwise, a company pioneering genetics-based innovation in food and agriculture, has developed the world’s first seedless blackberry. Created using the company’s proprietary Fulcrum™ Platform, a complete suite of novel tools for CRISPR application in plants, this is the first time seedlessness has been achieved in any caneberry.
“We are thrilled to share this breakthrough achievement from our talented R&D team. Pairwise scientists have used their deep knowledge of plant genetics, broad suite of CRISPR tools, and multiplex editing techniques to eliminate the hard pits in berry fruit, creating soft, small seeds like those found in grapes and watermelon that are commonly labeled as seedless,” said Ryan Bartlett, Pairwise Chief Technology Officer. “The result is the first seedless blackberry in the world. We expect that this trait will not only transform the blackberry market, but it also lays the groundwork for accelerated progress in removing seeds and pits in many other fruits such as cherries.”
Recent innovations in produce have been rapidly adopted due to the significant benefits they provide consumers, such as improved flavor, consistency, and convenience.
“The berry variety we edited is consistently sweet year-round and holds up well during shipment; now, consumers will have the option to choose a nutritious blackberry without seeds that also reliably delivers great flavor and quality,” said Haven Baker, Pairwise Co-Founder and Chief Business Officer. “Blackberries are a snackable fruit with significant health benefits; however, data indicates that more than 30% of berry buyers do not like the seeds, and many more do not even buy the fruit because of the seeds.”
In addition to creating the first seedless caneberry, Pairwise has successfully edited the same variety to eliminate thorns and create a more compact plant that delivers benefits for harvesters, growers, and the environment. The thornless and compact traits enable more efficient fruit harvesting and improved productivity and profitability for growers. The new compact trait means the plants are smaller and can be planted at a higher density per acre.
With the precision of CRISPR, we’re able to develop these thornless and compact traits without sacrificing consistency in flavor and quality for consumers,” said Baker. “We’re excited to advance these berries into the next phase of product development, including outdoor field trials, as we work toward scaling up and making them available to the public in a few years.”
“A key challenge in our food system is helping people eat more high-quality, healthy foods. As part of our drive to increase the consumption of fruit and vegetables, we’re working to provide consumers with new, highly nutritious food options with improved flavor and convenience,” said Tom Adams, Pairwise Co-Founder and CEO. “With a deep understanding of the plant genome, an accurate, efficient, and scalable process, and streamlined pathway to commercialization, we are not only creating new products with our proprietary CRISPR technology, we are creating a new era of innovation in agriculture.”
Learn more about Pairwise and its proven Fulcrum Platform here.
About Pairwise:
Pairwise is pioneering the application of CRISPR technology in food and agriculture. The company brings together leaders in agriculture, technology, and consumer foods to harness the transformative potential of new genomics technologies to create innovative new products. Pairwise is working to develop new varieties of crops, and to partner with organizations that seek to deliver innovation across the plant-based economy. Backed by industry leading investors Deerfield, Aliment Capital, Leaps by Bayer, and Temasek, Pairwise raised $90 million in a successful series B funding round in February 2021, bringing total fundraising to $115 million. The company was founded by Chief Executive Officer Tom Adams and Chief Business Officer Haven Baker, with scientific co-founders J. Keith Joung, Lead Translator at Arena BioWorks; David Liu, Director of the Merkin Institute of Transformative Technologies in Healthcare, and Vice-Chair of the Faculty at the Broad Institute of Harvard and MIT; and Feng Zhang, McGovern Investigator and a professor at MIT. For more information, visit Pairwise.com, and learn more about the differentiating Pairwise Fulcrum™ Platform here.
Pairwise, a food and agriculture company known for bringing the first gene-edited food to the U.S. market, and Bayer today announced a new five-year, multi-million dollar agreement focused on innovations in short-stature corn. This new program leverages Pairwise’s Fulcrum™ platform and builds on the success of the companies’ initial five-year collaboration for corn, soy, wheat, cotton, and canola.
The upcoming collaboration between Pairwise and Bayer will be focused on optimizing and enhancing gene-edited short-stature corn for future use in Bayer’s Preceon™ Smart Corn System. Short-stature corn – with a targeted height of 30 to 40 percent less than traditional corn – is an innovative new approach to growing corn and offers a number of sustainability benefits, including protections from crop loss due to increasingly severe weather events and extreme winds brought about by climate change. Short-stature corn also allows for more precise application of inputs throughout the growing season, sustainably growing more through reduced risk of crop loss.
“Pairwise’s proprietary base editing tools allow for specific changes at virtually any location in the genome, which has the potential to make targeted and much needed improvements in agriculture,” said Bob Reiter, Head of R&D at Bayer’s Crop Science Division. "These kinds of new genomic techniques are extraordinarily focused and produce results much more quickly and precisely than the conventional breeding process, ensuring that we can accelerate the delivery of solutions that growers need."
The initial five-year collaboration focused on corn, soy, wheat, cotton and canola with the aim of empowering producers to grow more with fewer inputs on the same amount of land. The partnership, which concluded in June 2023, resulted in 27 novel traits being transferred into Bayer’s testing programs. Results of the program demonstrated significant commercial value including edited corn phenotypes with a 20 percent increase in kernel row numbers, which could lead to significantly more yield on the same number of acres. Another outcome has been edited soy that reduces the severity of Asian soybean rust, potentially reducing the need for fungicides to combat the disease and protecting the potential for higher yields.
These, and other significant achievements, were made possible through the development of custom gene editing tools by Pairwise. These include REDRAW™, or RNA encoded DNA replacement of alleles with CRISPR, a precise templated editing toolbox that can make any type of small edit at CRISPR-targeted sites. Another tool is SHARC™, a proprietary enzyme that works well for cutting, base editing, and REDRAW editing. These tools will also be used in the new collaboration focused on advancing short-stature corn.
“We look forward to continuing our work with Bayer, with new emphasis on contributing to their novel smart corn system,” added Tom Adams, Co-founder and CEO at Pairwise. “Working closely with Bayer on furthering this revolution in corn gives us the market reach to enable our technology innovations to more quickly adjust to the biggest challenge of our time: the changing climate.”
Pairwise has already demonstrated the successful use of CRISPR and other emerging technologies to accelerate the delivery of new products to markets, and recently launched its first product, Conscious™ Greens into the U.S. foodservice channel. Through the leading use of cutting-edge technologies, and due to the efficiency of the company’s Fulcrum Platform, the product was advanced from concept to commercialization in just four years. In addition, Pairwise works with other innovative companies and has licensed its IP for applications in additional crops of global importance, including licensing elements of the Fulcrum Platform to Tropic Biosciences for applications in banana and coffee.
About Bayer:
Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Its products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2022, the Group employed around 101,000 people and had sales of 50.7 billion euros. R&D expenses before special items amounted to 6.2 billion euros. For more information, go to www.bayer.com.
Bayer Media inquiries:
Alex Hennig
+49 175 30-89736
Forward-Looking Statements: This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer’s public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.
Bayer Media Inquiries:
Alex Hennig
+49 175 30-89736
Bayer Investor Inquiries:
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+49 214 30-72704
Pairwise is pioneering the application of CRISPR technology in food and agriculture.
